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Serpinh1tm2Kzn
Targeted Allele Detail
Summary
Symbol: Serpinh1tm2Kzn
Name: serine (or cysteine) peptidase inhibitor, clade H, member 1; targeted mutation 2, Kazuhiro Nagata
MGI ID: MGI:5505265
Synonyms: Hsp47flox
Gene: Serpinh1  Location: Chr7:98994583-99002446 bp, - strand  Genetic Position: Chr7, 54.07 cM
Alliance: Serpinh1tm2Kzn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197791
Parent Cell Line:  KY1.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 6. An FRT-flanked neo cassette with a 3'loxP site was inserted downstream of exon 6. (J:197791)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Serpinh1 Mutation:  52 strains or lines available
References
Original:  J:197791 Masago Y, et al., The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation. J Cell Sci. 2012 Mar 1;125(Pt 5):1118-28
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory