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P4hbtm1.2Geno
Targeted Allele Detail
Nomenclature
Symbol: P4hbtm1.2Geno
Name: prolyl 4-hydroxylase, beta polypeptide; targeted mutation 1.2, Genoway
MGI ID: MGI:5504625
Synonyms: PDI-
Gene: P4hb  Location: Chr11:120560298-120573253 bp, - strand  Genetic Position: Chr11, 84.27 cM, cytoband D-E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197556
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3'loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 1 and 2 floxed. Cre-mediated recombination removed exons 1 and 2. (J:197556)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P4hb Mutation:  24 strains or lines available
References
Original:  J:197556 Hahm E, et al., Extracellular protein disulfide isomerase regulates ligand-binding activity of alphaMbeta2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013 May 9;121(19):3789-800, S1-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory