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Ggntm1Dpj
Targeted Allele Detail
Nomenclature
Symbol: Ggntm1Dpj
Name: gametogenetin; targeted mutation 1, Duangporn Jamsai
MGI ID: MGI:5503309
Gene: Ggn  Location: Chr7:29170210-29173938 bp, + strand  Genetic Position: Chr7, 16.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199404
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA kanamycin/neomycin resistance cassette replaced the coding sequence. Western blot analysis confirmed reduced protein expression in spermatocytes from heterozygotes. (J:199404)
Generation of the Ggntm1Dpj allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ggn Mutation:  15 strains or lines available
References
Original:  J:199404 Jamsai D, et al., Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. PLoS One. 2013;8(2):e56955
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory