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Slc5a10tm1Csk
Targeted Allele Detail
Summary
Symbol: Slc5a10tm1Csk
Name: solute carrier family 5 (sodium/glucose cotransporter), member 10; targeted mutation 1, Chugai Pharmaceutical Co, Ltd
MGI ID: MGI:5503305
Gene: Slc5a10  Location: Chr11:61563608-61611641 bp, - strand  Genetic Position: Chr11, 37.96 cM
Alliance: Slc5a10tm1Csk page
Increase in liver triglyceride levels in Slc5a10tm1Csk/Slc5a10tm1Csk mice fed a high fructose diet

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199406
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced part of exon 3 through part of exon 6. (J:199406)
Generation of the Slc5a10tm1Csk allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc5a10 Mutation:  20 strains or lines available
References
Original:  J:199406 Fukuzawa T, et al., SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. PLoS One. 2013;8(2):e56681
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory