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Targeted Allele Detail
Symbol: Nfkbiztm1.1Muta
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1.1, Tatsushi Muta
MGI ID: MGI:5501251
Gene: Nfkbiz  Location: Chr16:55631740-55659004 bp, - strand  Genetic Position: Chr16, 33.65 cM, cytoband C1.2 - C1.3
Germline Transmission:  Earliest citation of germline transmission: J:194832
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted in intron 4 and an FRT flanked neomycin selection cassette followed by a second loxP site was inserted in intron 7. The selection cassette was excised from properly targeted mice by flp recombinase. (J:194832)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfkbiz Mutation:  23 strains or lines available
Original:  J:194832 Okuma A, et al., Enhanced Apoptosis by Disruption of the STAT3-IkappaB-zeta Signaling Pathway in Epithelial Cells Induces Sjogren's Syndrome-like Autoimmune Disease. Immunity. 2013 Mar 21;38(3):450-60
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory