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Targeted Allele Detail
Symbol: Kdm6atm1.2Afst
Name: lysine (K)-specific demethylase 6A; targeted mutation 1.2, A Stewart
MGI ID: MGI:5499291
Synonyms: UTXFD
Gene: Kdm6a  Location: ChrX:18162575-18279936 bp, + strand  Genetic Position: ChrX, 13.45 cM
Germline Transmission:  Earliest citation of germline transmission: J:196401
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked STOP cassette with a 3' loxP site was inserted upstream of exon 3. A rox flanked hygromycin resistance (hygro) cassette with a 3' loxP site was inserted downstream of exon 3. Flp- and dre-mediated recombination removed the STOP and hygro cassettes. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression. (J:196401)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm6a Mutation:  38 strains or lines available
Original:  J:196401 Thieme S, et al., The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood. 2013 Mar 28;121(13):2462-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory