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Crb1rd8+em1Mvw
Endonuclease-mediated Allele Detail
Nomenclature
Symbol: Crb1rd8+em1Mvw
Name: crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated revertant 1, Michael Wiles
MGI ID: MGI:5498686
Synonyms: corrected, Crb1cor, Crb1em1Mvw
Gene: Crb1  Location: Chr1:139197056-139377100 bp, - strand  Genetic Position: Chr1, 60.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:206789
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NJ
Mutation
description
Allele Type:    Endonuclease-mediated
Mutation:    Insertion
 
Mutation detailsTALEN targeting of exon 9 for homologous recombination with single stranded oligonucleotides (ssODNs) replaces the deleted nucleotide (C/G) in the retinal degeneration 8 (rd8) mutation and incorporates 5 synonymous base substitutions inside the TALEN binding regions. (J:206789)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crb1 Mutation:  26 strains or lines available
References
Original:  J:206789 Low BE, et al., Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci. 2014 Jan;55(1):387-95
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory