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Targeted Allele Detail
Symbol: Usp10tm1Fuj
Name: ubiquitin specific peptidase 10; targeted mutation 1, Masahiro Fujii
MGI ID: MGI:5498660
Synonyms: Usp10delta
Gene: Usp10  Location: Chr8:119910360-119957560 bp, + strand  Genetic Position: Chr8, 68.61 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:194412
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 3 was deleted. RT-PCR confirmed a peptide product consistent with 30 N-terminal amino acids and 11 amino acids from an "out of frame" exon 4 translation. Western blot analysis confirmed the absence of native protein. This allele was generated from Usp10tm2.1Fuj (J:194412)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Usp10 Mutation:  24 strains or lines available
Original:  J:194412 Takahashi M, et al., Stress granules inhibit apoptosis by reducing reactive oxygen species production. Mol Cell Biol. 2013 Feb;33(4):815-29
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory