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b2b2110Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b2110Clo
Name: Mutant line 2110; Bench to Bassinet Program (B2B/CVDC), mutation 2110 Cecilia Lo
MGI ID: MGI:5498488
Synonyms: Weasley
Gene: b2b2110Clo  Location: unknown  
Mutant 2110-002-2 (E14.5) exhibits hypoplastic transverse arch with posterior positioning of the pulmonary artery, consistent with the finding of double outlet right ventricle by EFIC examination

Show the 11 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
 
Mutation detailsThis ENU-induced mutation line was isolated in a screen at the University of Pittsburgh. More than one mutation in this line results in a discernible phenotype in a homozygous recessive screen. At least two segregating phenotype groups are identified. See b2b2110.1Clo and b2b2110.2Clo (J:175213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b2110Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Mutant Type 1: Cardiac phenotype (1 mutant): Double outlet right ventricle (DORV) with hypoplastic aortic arch
Mutant Type 2: Cardiac phenotype: Biventricular hypertrophy
Noncardiac phenotype: Anopthalmia/micropthalmia, craniofacial defects including agnathia, micrognathia and cleft palate

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0600 Double outlet right ventricle
2704 Aortic arch hypoplasia
4163 Micrognathia
4876 Cleft palate
7505 Biventricular hypertrophy

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory