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Aloxe3tm1.2Krie
Targeted Allele Detail
Nomenclature
Symbol: Aloxe3tm1.2Krie
Name: arachidonate lipoxygenase 3; targeted mutation 1.2, Peter Krieg
MGI ID: MGI:5496904
Synonyms: eLOX-3-
Gene: Aloxe3  Location: Chr11:69125896-69149115 bp, + strand  Genetic Position: Chr11, 42.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196489
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxp site was inserted downstream of exon 5. Flp-mediated recombination removed the neomycin resistance cassette and left exons 2 through 5 floxed. Cre-mediated recombination removed exons 2 through 5. Western blot analysis confirmed the absence of protein expression in neonatal mouse epidermis. (J:196489)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aloxe3 Mutation:  25 strains or lines available
References
Original:  J:196489 Krieg P, et al., Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol. 2013 Jan;133(1):172-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory