Gdf15^tm1Breit
Targeted Allele Detail

Summary

• Symbol: Gdf15^tm1Breit
• Name: growth differentiation factor 15; targeted mutation 1, Samuel Breit
• MGI ID: MGI:5496693
• Synonyms: MIC-1^-
• Gene: Gdf15 Location: Chr8:71082043-71085106 bp, - strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Gdf15^tm1Breit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197174
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The second exon of Gdf15 (MIC-1) is deleted, removing the poly A tract and amino acids 94-302. (J:197174)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf15 Mutation: 26 strains or lines available

References

• Original: J:197174 Tsai VW, et al., TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS One. 2013;8(2):e55174
• All: 3 reference(s)