About   Help   FAQ
Phf2tm1.1Yima
Targeted Allele Detail
Summary
Symbol: Phf2tm1.1Yima
Name: PHD finger protein 2; targeted mutation 1.1, Yuuki Imai
MGI ID: MGI:5496656
Synonyms: Phf2Z
Gene: Phf2  Location: Chr13:48955226-49024361 bp, - strand  Genetic Position: Chr13, 24.96 cM, cytoband A3-A4
Alliance: Phf2tm1.1Yima page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198329
Parent Cell Line:  M1/M-1 (ES Cell)
Strain of Origin:  (129 x C57BL/6)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe construct targeted upstream of exon 6 contains (5' to 3') a loxP site, lacZ gene, FRT site, neomycin resistance cassette, loxP site and FRT site. An additional FRT site was inserted downstream of exon 6. Flp-mediated recombination removed the neomycin resistance cassette and exon 6 but left the lacZ gene intact. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:198329)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phf2 Mutation:  45 strains or lines available
References
Original:  J:198329 Okuno Y, et al., Epigenetic regulation of adipogenesis by PHF2 histone demethylase. Diabetes. 2013 May;62(5):1426-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory