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Targeted Allele Detail
Symbol: Celf6tm1.2Jdd
Name: CUGBP, Elav-like family member 6; targeted mutation 1.2, Joseph D Dougherty
MGI ID: MGI:5494708
Gene: Celf6  Location: Chr9:59485200-59514575 bp, + strand  Genetic Position: Chr9, 32.02 cM
Germline Transmission:  Earliest citation of germline transmission: J:194266
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsLoxP sites were inserted, with an adjacent FRT flanked neomycin resistance cassette, upstream and downstream of exon 4. Mice were subsequently mated to flp expressing mice and the offspring mated to cre expressing mice to delete, first, the selection cassette, and then exon 4. Quantitative RT-PCR from mouse brain confirmed decreased mRNA. Immunological studies confirmed the absence of protein product in the brain. (J:194266)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Celf6 Mutation:  18 strains or lines available
Original:  J:194266 Dougherty JD, et al., The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. J Neurosci. 2013 Feb 13;33(7):2732-53
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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