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Syne4tm1Kare
Targeted Allele Detail
Summary
Symbol: Syne4tm1Kare
Name: spectrin repeat containing, nuclear envelope family member 4; targeted mutation 1, Karen B Avraham
MGI ID: MGI:5494678
Gene: Syne4  Location: Chr7:30014268-30018471 bp, + strand  Genetic Position: Chr7, 17.39 cM
Alliance: Syne4tm1Kare page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194486
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES, lacZ and floxed neomycin resistance cassette replaced exons 2 through 6. Western blot analysis confirmed the absence of protein expression in salivary gland cells. (J:194486)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syne4 Mutation:  22 strains or lines available
References
Original:  J:194486 Horn HF, et al., The LINC complex is essential for hearing. J Clin Invest. 2013 Feb;123(2):740-50
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory