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Ston2tm1Vha
Targeted Allele Detail
Nomenclature
Symbol: Ston2tm1Vha
Name: stonin 2; targeted mutation 1, Volker Haucke
MGI ID: MGI:5494671
Gene: Ston2  Location: Chr12:91633009-91786436 bp, - strand  Genetic Position: Chr12, 45.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194336
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette replaced 1.3 kb of the coding sequence in exon 5, which comprises 70% of the coding sequence. Western blot analysis confirmed the absence of protein expression in the brain. (J:194336)
Generation of the Ston2tm1Vha allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ston2 Mutation:  29 strains or lines available
Notes
ES cell = ES14.
References
Original:  J:194336 Kononenko NL, et al., Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E526-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory