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Endonuclease-mediated Allele Detail
Symbol: Albem8Mvw
Name: albumin; endonuclease-mediated mutation 8, Michael Wiles
MGI ID: MGI:5494601
Synonyms: Alb-
Gene: Alb  Location: Chr5:90608756-90624461 bp, + strand  Genetic Position: Chr5, 44.7 cM
Strain of Origin:  C57BL/6J
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Intragenic deletion, Single point mutation
Mutation detailsExon 4 was targeted by introduction of TALEN mRNA into fertilized C57BL/6J oocytes and the resulting founder screened and found to have a 1 base pair deletion at Chromosome 5 base 90,464,113 (GRCm38.p2) which is predicted to result in a frame shift then a premature stop codon 55 amino acids downstream of the encoded frame shift. By ELISA, heterozgyotes have a decrease in serum albumin of approximately 30 percent and homozygotes have no detectable serum albumin. (J:220803)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Alb Mutation:  64 strains or lines available
Original:  J:220803 Roopenian DC, et al., Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs. MAbs. 2015;7(2):344-51
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory