Fbxl3^tm1.1Ljp
Targeted Allele Detail

Summary

• Symbol: Fbxl3^tm1.1Ljp
• Name: F-box and leucine-rich repeat protein 3; targeted mutation 1.1, Louis J Ptacek
• MGI ID: MGI:5494565
• Gene: Fbxl3 Location: Chr14:103317675-103337002 bp, - strand Genetic Position: Chr14, 51.73 cM, cytoband E2.2
• Alliance: Fbxl3^tm1.1Ljp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194250
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT flanked neomycin selection cassette followed by a second loxP site was inserted downstream. Exon 5 is thus flanked by loxP SITES. Exon 5 was then removed from properly targeted mice by cre excision. (J:194250)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxl3 Mutation: 41 strains or lines available

References

• Original: J:194250 Shi G, et al., Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4750-5
• All: 2 reference(s)