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Agr2tm1.1Lex
Targeted Allele Detail
Nomenclature
Symbol: Agr2tm1.1Lex
Name: anterior gradient 2; targeted mutation 1.1, Lexicon Genetics
MGI ID: MGI:5494472
Gene: Agr2  Location: Chr12:35992925-36004081 bp, + strand  Genetic Position: Chr12, 16.18 cM
Mucosal hyperplasia in glandular stomach of Agr2tm1.1Lex/Agr2tm1.1Lex mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195573
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exons 2 through 5. QRT-PCR confirmed the absence of transcript expression in the stomach. (J:195573)
Schematic of the Agr2tm1.1Lex allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agr2 Mutation:  14 strains or lines available
References
Original:  J:195573 Gupta A, et al., Loss of anterior gradient 2 (Agr2) expression results in hyperplasia and defective lineage maturation in the murine stomach. J Biol Chem. 2013 Feb 8;288(6):4321-33
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory