Slc5a6^tm1.1Said
Targeted Allele Detail

Summary

• Symbol: Slc5a6^tm1.1Said
• Name: solute carrier family 5 (sodium-dependent vitamin transporter), member 6; targeted mutation 1.1, Hamid M Said
• MGI ID: MGI:5493496
• Synonyms: SMVT KO
• Gene: Slc5a6 Location: Chr5:31193380-31206268 bp, - strand Genetic Position: Chr5, 16.93 cM
• Alliance: Slc5a6^tm1.1Said page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194700
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted 5" of exon 4. An FRT flanked neomycin selection cassette was inserted in intron 6. A second loxP site was also inserted in intron 6 downstream of the selection cassette and the selection cassette was subsequently removed from properly targeted mice by crossing to mice expressing flp recombinase leaving exons 4-6 flanked by loxP sites. Targeting was performed by inGenious Targeting Laboratory. (J:194700)

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc5a6 Mutation: 27 strains or lines available

References

• Original: J:194700 Ghosal A, et al., Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G64-71
• All: 4 reference(s)