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Mdktm1.1(KOMP)Mbp
Targeted Allele Detail
Nomenclature
Symbol: Mdktm1.1(KOMP)Mbp
Name: midkine; targeted mutation 1.1, Mouse Biology Program, UCDavis
MGI ID: MGI:5493326
Gene: Mdk  Location: Chr2:91929805-91932297 bp, - strand  Genetic Position: Chr2, 50.63 cM
Mutation
origin
Mutant Cell Line:  DEPD00513_1_C09 (Mouse Biology Program, University of California, Davis)
Germline Transmission:  Earliest citation of germline transmission: J:188991
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 697 starting at position 91931456 and ending at position 91930759 of Chromosome 2 (Genome Build GRCm38). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by neomycin under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Subsequent cre-mediated excision removed the neomycin selection cassette. Further information on targeting strategies used for this and other KOMP alleles can be found at http://www.knockoutmouse.org/aboutkompstrategies. (J:157064, J:188991)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mdk Mutation:  40 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory