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Irf8tm1.2Hm
Targeted Allele Detail
Nomenclature
Symbol: Irf8tm1.2Hm
Name: interferon regulatory factor 8; targeted mutation 1.2, Herbert Morse III
MGI ID: MGI:5491303
Gene: Irf8  Location: Chr8:120736358-120756694 bp, + strand  Genetic Position: Chr8, 70.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205655
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 2 was floxed. Cre-mediated recombination removed exon 2. (J:168923)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:  11 strains or lines available
References
Original:  J:205655 Ouyang X, et al., Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. Nat Commun. 2011;2:314
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory