Irf8^tm1.2Hm
Targeted Allele Detail

Summary

• Symbol: Irf8^tm1.2Hm
• Name: interferon regulatory factor 8; targeted mutation 1.2, Herbert Morse III
• MGI ID: MGI:5491303
• Gene: Irf8 Location: Chr8:121463097-121483433 bp, + strand Genetic Position: Chr8, 70.05 cM
• Alliance: Irf8^tm1.2Hm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205655
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was floxed. Cre-mediated recombination removed exon 2. (J:168923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf8 Mutation: 32 strains or lines available

References

• Original: J:205655 Ouyang X, et al., Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation. Nat Commun. 2011;2:314
• All: 20 reference(s)