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Tg(Prnp*P101L)2862Sbp
Transgene Detail
Nomenclature
Symbol: Tg(Prnp*P101L)2862Sbp
Name: transgene insertion 2862, Stanley B Prusiner
MGI ID: MGI:5491026
Synonyms: Tg(MoPrP-P101L)2862
Transgene: Tg(Prnp*P101L)2862Sbp  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp*P101L)2862Sbp expresses 1 gene
 
Mutation detailsThis transgene construct consists of the mouse Prnp containing a substitution of a leucine for proline codon at residue 101, corresponding to the Gerstmann-Straussler-Scheinker disease mutation at codon 102 of the human PRNP gene, in the cosSHa.Tet vector. This line overexpresses the transgene about 32-fold. Three lines were generated; 2247, 2866, and 2862 (J:136434)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:136434 Telling GC, et al., Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev. 1996 Jul 15;10(14):1736-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory