Adcy6^tm1.1Dek
Targeted Allele Detail

Summary

• Symbol: Adcy6^tm1.1Dek
• Name: adenylate cyclase 6; targeted mutation 1.1, Donald E Kohan
• MGI ID: MGI:5490599
• Gene: Adcy6 Location: Chr15:98487854-98507957 bp, - strand Genetic Position: Chr15, 54.59 cM, cytoband F
• Alliance: Adcy6^tm1.1Dek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180012
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a frt-flanked neomycin resistance (neo) cassette followed by a loxP site upstream of exon 3, and a second loxP site downstream of exon 12 of the adenylate cyclase 6 (Adcy6) gene. Flp-mediated recombination removed the neo cassette and left exons 3 through 12 floxed. (J:180012)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adcy6 Mutation: 49 strains or lines available

References

• Original: J:180012 Roos KP, et al., Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice. Am J Physiol Renal Physiol. 2012 Jan;302(1):F78-84
• All: 8 reference(s)