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Ampd2tm1Tm
Targeted Allele Detail
Nomenclature
Symbol: Ampd2tm1Tm
Name: adenosine monophosphate deaminase 2; targeted mutation 1, Takayuki Morisaki
MGI ID: MGI:5490144
Gene: Ampd2  Location: Chr3:108074062-108086651 bp, - strand  Genetic Position: Chr3, 46.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196782
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA puro cassette replaced exons 15 and 16. Western blot analysis confirmed the absence of protein expression in the liver, kidney, lung, spleen, testis and brain. (J:196782)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ampd2 Mutation:  5 strains or lines available
References
Original:  J:196782 Toyama K, et al., Proteinuria in AMPD2-deficient mice. Genes Cells. 2012 Jan;17(1):28-38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory