Ampd2^tm1Tm
Targeted Allele Detail

Summary

• Symbol: Ampd2^tm1Tm
• Name: adenosine monophosphate deaminase 2; targeted mutation 1, Takayuki Morisaki
• MGI ID: MGI:5490144
• Gene: Ampd2 Location: Chr3:107981378-107993967 bp, - strand Genetic Position: Chr3, 46.83 cM
• Alliance: Ampd2^tm1Tm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196782
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A puro cassette replaced exons 15 and 16. Western blot analysis confirmed the absence of protein expression in the liver, kidney, lung, spleen, testis and brain. (J:196782)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ampd2 Mutation: 44 strains or lines available

References

• Original: J:196782 Toyama K, et al., Proteinuria in AMPD2-deficient mice. Genes Cells. 2012 Jan;17(1):28-38
• All: 4 reference(s)