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Cbx4tm1.2Gxu
Targeted Allele Detail
Nomenclature
Symbol: Cbx4tm1.2Gxu
Name: chromobox 4; targeted mutation 1.2, Guo-Liang Xu
MGI ID: MGI:5489932
Gene: Cbx4  Location: Chr11:119077573-119086221 bp, - strand  Genetic Position: Chr11, 83.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194053
Parent Cell Line:  MPI-II (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exons 1 and 2. (J:194053)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cbx4 Mutation:  13 strains or lines available
References
Original:  J:194053 Liu B, et al., Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb;140(4):780-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory