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Or8a1tm37(Or10j5*,Gnas*)Mom
Targeted Allele Detail
Summary
Symbol: Or8a1tm37(Or10j5*,Gnas*)Mom
Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 37, Peter Mombaerts
MGI ID: MGI:5489810
Synonyms: MOR23/M71-RDY-caGs, MOR23(RDY)->M71-caGs-Tomato, Olfr151tm37(Olfr16*,-Gnas,-tdTomato)Mom, Or8a1tm37(Olfr16*,Gnas*)Mom
Gene: Or8a1  Location: Chr9:37641273-37642357 bp, - strand  Genetic Position: Chr9, 20.8 cM
Alliance: Or8a1tm37(Or10j5*,Gnas*)Mom page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233447
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Constitutively active, Inserted expressed sequence)
Mutations:    Insertion, Nucleotide substitutions
 
Or8a1tm37(Or10j5*,Gnas*)Mom expresses 2 genes
 
Mutation detailsThe endogenous coding sequence was replaced with a mutated Or10j5 sequence, in which the DRY motif was replaced by RDY (D121R;R122D), followed by an internal ribosome entry site and a constitutively active form of Gnas, followed by another internal ribosome entry site and a Tau-tdTomato reporter, in addition to a self-excising neomycin selection cassette (ACNF), thus encoding a tri-cistronic message that has a signaling-deficient OR10J5 olfactory receptor, a constitutively active GNAS to rescue G-protein signaling, and a fluorescent reporter. (J:233447)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Or8a1 Mutation:  69 strains or lines available
References
Original:  J:233447 Movahedi K, et al., Odorant receptors can mediate axonal identity and gene choice via cAMP-independent mechanisms. Open Biol. 2016 Jul;6(7)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory