Gpm6b^tm1Kan
Targeted Allele Detail

Summary

• Symbol: Gpm6b^tm1Kan
• Name: glycoprotein m6b; targeted mutation 1, Klaus-Armin Nave
• MGI ID: MGI:5487806
• Gene: Gpm6b Location: ChrX:165021907-165171984 bp, + strand Genetic Position: ChrX, 76.86 cM
• Alliance: Gpm6b^tm1Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193310
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exons 4 and 5 and all of intron 4 were replaced with a neo cassette via homologous recombination. RT-PCR and immunoblot analysis confirmed the absence of transcript and protein expression in null mice. (J:193310)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpm6b Mutation: 5 strains or lines available

References

• Original: J:193310 Werner HB, et al., A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Glia. 2013 Apr;61(4):567-86
• All: 4 reference(s)