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Targeted Allele Detail
Symbol: Gpm6btm1Kan
Name: glycoprotein m6b; targeted mutation 1, Klaus-Armin Nave
MGI ID: MGI:5487806
Gene: Gpm6b  Location: ChrX:166238911-166388988 bp, + strand  Genetic Position: ChrX, 76.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:193310
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exons 4 and 5 and all of intron 4 were replaced with a neo cassette via homologous recombination. RT-PCR and immunoblot analysis confirmed the absence of transcript and protein expression in null mice. (J:193310)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpm6b Mutation:  1 strain or line available
Original:  J:193310 Werner HB, et al., A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system. Glia. 2013 Apr;61(4):567-86
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory