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Targeted Allele Detail
Symbol: Sqstm1tm2.1Jmos
Name: sequestosome 1; targeted mutation 2.1, Jorge Moscat
MGI ID: MGI:5487454
Synonyms: p62fl, p62loxp
Gene: Sqstm1  Location: Chr11:50200152-50210820 bp, - strand  Genetic Position: Chr11, 30.36 cM, cytoband B1.2
Enhanced lipid deposition with increased lipid droplet sizes of brown adipose tissue in Sqstm1tm2.1Jmos/Sqstm1tm2.1Jmos Tg(Fabp4-cre)1Rev/0 mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:194291
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed (J:194291)
Generation of the Sqstm1tm2.1Jmos allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sqstm1 Mutation:  19 strains or lines available
Original:  J:194291 Muller TD, et al., p62 links beta-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest. 2013 Jan 2;123(1):469-78
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory