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Targeted Allele Detail
Symbol: Cxcl12tm1.1Sjm
Name: chemokine (C-X-C motif) ligand 12; targeted mutation 1.1, Sean J Morrison
MGI ID: MGI:5486672
Synonyms: Cxcl12fl
Gene: Cxcl12  Location: Chr6:117168535-117181367 bp, + strand  Genetic Position: Chr6, 54.81 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:194748
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted 5' of exon 2 and an Frt-Neo-Frt-loxP cassette was placed 3' of the same exon. The selection cassette was subsequently removed by crossing with mice expressing flp recombinase. Condition cre expression creates a frame shift mutation. (J:194748)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcl12 Mutation:  10 strains or lines available
Original:  J:194748 Ding L, et al., Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013 Mar 14;495(7440):231-5
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory