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Macroh2a1tm1Mbou
Targeted Allele Detail
Nomenclature
Symbol: Macroh2a1tm1Mbou
Name: macroH2A.1 histone; targeted mutation 1, Mathieu Boulard
MGI ID: MGI:5485999
Gene: Macroh2a1  Location: Chr13:56073622-56135626 bp, - strand  Genetic Position: Chr13, 30.06 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195833
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette replaced exon 2. Western blot anlaysis confirmed the absence of protein expression in the brain, liver, testis, spleen, kidney and thymus. (J:195833)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Macroh2a1 Mutation:  44 strains or lines available
References
Original:  J:195833 Boulard M, et al., Histone variant macroH2A1 deletion in mice causes female-specific steatosis. Epigenetics Chromatin. 2010;3(1):8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory