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Transgenic Allele Detail
Symbol: E2f1Tg(Wnt1-cre)2Sor
Name: E2F transcription factor 1; transgene insertion 2, Philippe Soriano
MGI ID: MGI:5485027
Synonyms: Tg(Wnt1-cre)2Sor, Wnt1-Cre, Wnt1-Cre2
Gene: E2f1  Location: Chr2:154401327-154411812 bp, - strand  Genetic Position: Chr2, 76.79 cM
Strain of Origin:  C57BL/6 x C3H
Transgene Type:    Transgenic (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion, Inversion
Mutation detailsA transgenic insert containing cre recombinase, under the control of the 1.3 kb 5' promoter and 5.5 kb 3' enhancer of the mouse Wnt1, wingless-related MMTV integration site 1 was injected into fertilized B6C3 hybrid mouse eggs. Founder line 2 inserted into the gene at 154561346-154561603 (Build GRCm38/mm10) resulting in a 257 bp deletion and a 45 Kb inverted segment in exon 5 of the gene. The inversion contains all of exon 5, but deletes 23 Kb including exons 6 and 7. Founder line 2 has a copy number of 1-3. (J:195690)
 Tissue activity of this recombinase allele
Driver: Wnt1     Summary of all recombinase alleles driven by Wnt1. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 37 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any E2f1 Mutation:  25 strains or lines available
Original:  J:199477 Lewis AE, et al., The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15;379(2):229-34
All:  81 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory