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E2f1Tg(Wnt1-cre)2Sor
Transgenic Allele Detail
Nomenclature
Symbol: E2f1Tg(Wnt1-cre)2Sor
Name: E2F transcription factor 1; transgene insertion 2, Philippe Soriano
MGI ID: MGI:5485027
Synonyms: Tg(Wnt1-cre)2Sor, Wnt1-Cre2
Gene: E2f1  Location: Chr2:154559407-154569892 bp, - strand  Genetic Position: Chr2, 76.79 cM
Transgene
origin
Strain of Origin:  C57BL/6 x C3H
Transgene
description
Transgene Type:    Transgenic (Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion, Inversion
 
Mutation detailsA transgenic insert containing cre recombinase, under the control of the 1.3 kb 5' promoter and 5.5 kb 3' enhancer of the mouse Wnt1, wingless-related MMTV integration site 1 was injected into fertilized B6C3 hybrid mouse eggs. Founder line 2 inserted into the gene at 154561346-154561603 (Build GRCm38/mm10) resulting in a 257 bp deletion and a 45 Kb inverted segment in exon 5 of the gene. The inversion contains all of exon 5, but deletes 23 Kb including exons 6 and 7. Founder line 2 has a copy number of 1-3. (J:195690, J:253473)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Wnt1     Summary of all recombinase alleles driven by Wnt1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any E2f1 Mutation:  5 strains or lines available
References
Original:  J:199477 Lewis AE, et al., The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Dev Biol. 2013 Jul 15;379(2):229-34
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory