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Tg(LCR-HBA1,LCR-HBB*)1Tow
Transgene Detail
Nomenclature
Symbol: Tg(LCR-HBA1,LCR-HBB*)1Tow
Name: transgene insertion 1, Timothy Townes
MGI ID: MGI:5484766
Synonyms: Tg(LCR-HBA1,-HBB*)1Tow
Transgene: Tg(LCR-HBA1,LCR-HBB*)1Tow  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(LCR-HBA1,LCR-HBB*)1Tow expresses 3 genes
 
Mutation detailsTwo transgenes were designed to each be controlled independently by five upstream sites (HS I-V) of the human beta-globin locus control regions (LCR). The HS I-V betaS transgene expresses a glutamic acid to valine mutation of the human hemoglobin beta chain complex (HBB) that has been linked to sickle cell disease. The HS I-V alpha transgene expresses a human alpha1 globin (HBA1) gene. Line 1 was generated. (J:127701)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:127701 Ryan TM, et al., Human sickle hemoglobin in transgenic mice. Science. 1990 Feb 2;247(4942):566-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory