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Edartm1.1Bamo
Targeted Allele Detail
Summary
Symbol: Edartm1.1Bamo
Name: ectodysplasin-A receptor; targeted mutation 1.1, Bruce A Morgan
MGI ID: MGI:5484581
Synonyms: 307A
Gene: Edar  Location: Chr10:58436611-58511476 bp, - strand  Genetic Position: Chr10, 29.37 cM, cytoband B3
Alliance: Edartm1.1Bamo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193816
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsHomologous recombination was used to introduce a T1326C point mutation resulting in a V370A substitution in the protein in exon 12 and a floxed neo cassette in the untranslated region of exon 12. Cre mediated recombination removed the neo cassette. (J:193816)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Edar Mutation:  30 strains or lines available
References
Original:  J:193816 Kamberov YG, et al., Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. Cell. 2013 Feb 14;152(4):691-702
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory