Fgf5^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Fgf5^m2Btlr
• Name: fibroblast growth factor 5; mutation 2, Bruce Beutler
• MGI ID: MGI:5478737
• Synonyms: splinter
• Gene: Fgf5 Location: Chr5:98402108-98424892 bp, + strand Genetic Position: Chr5, 47.77 cM, cytoband E1-F
• Alliance: Fgf5^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Capillary sequencing of the mutated gene identified a C to T transition at base pair 98261987 (v38) on chromosome 5 in the GenBank genomic region NC_000071 encoding Fgf5 (LOD = 4.56). The mutation corresponds to residue 394 in the mRNA sequence in exon 2 of 3 total exons. The mutation results in a substitution of arginine (R) to a premature stop codon at residue 132, and may cause nonsense-mediated decay of the transcript. (J:195411)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgf5 Mutation: 14 strains or lines available

References

• Original: J:195411 Beutler B, Direct Data Submission for splinter. MGI Direct Data Submission. 2013;v
• All: 1 reference(s)