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Targeted Allele Detail
Symbol: Npm1tm1Hft
Name: nucleophosmin 1; targeted mutation 1, Hwei-Fang Tien
MGI ID: MGI:5478640
Synonyms: Npm1c+
Gene: Npm1  Location: Chr11:33102287-33113206 bp, - strand  Genetic Position: Chr11, 19.21 cM
Splenomegaly and follicle structure changes in Npm1tm1Hft/Npm1+ mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:194999
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
Mutation detailsExon 11 was replaced with a floxed neo cassette and a modified exon 11 in which the wild-type sequence is replaced with a TCTG insertion after the coding sequence nucleotide 8657 (c.854_857dupTCTG). This "conventional" mutation mimics the human mutation observed in patients with acute myeloid leukemia (AML;type A, c.860_863dupTCTG) without any "humanized" sequence. (J:194999)
Generation of the Npm1tm1Hft allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npm1 Mutation:  25 strains or lines available
Original:  J:194999 Chou SH, et al., A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment. PLoS One. 2012;7(11):e49769
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory