Ube2o^{tm1.1(KOMP)Mbp}
Targeted Allele Detail

Summary

• Symbol: Ube2o^{tm1.1(KOMP)Mbp}
• Name: ubiquitin-conjugating enzyme E2O; targeted mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:5477804
• Gene: Ube2o Location: Chr11:116428566-116472273 bp, - strand Genetic Position: Chr11, 81.42 cM
• Alliance: Ube2o^{tm1.1(KOMP)Mbp} page
• IMPC: Ube2o gene page

Mutation origin

• Mutant Cell Line: DEPD00564_2_D02
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 7967 starting at position 116429889 and ending at position 116437856 of Chromosome 11 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Subsequent cre expression excised this neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:157064, J:188991)

Expression

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ube2o^{tm1.1(KOMP)Mbp}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ube2o Mutation: 57 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 6 reference(s)