Tg(CDX2-cre/ERT2)752Erf
Transgene Detail

Summary

• Symbol: Tg(CDX2-cre/ERT2)752Erf
• Name: transgene insertion 752, Eric Fearon
• MGI ID: MGI:5477802
• Synonyms: CDX2-creERT2, CDX2P9.5-NLSCre
• Transgene: Tg(CDX2-cre/ERT2)752Erf Location: unknown
• Alliance: Tg(CDX2-cre/ERT2)752Erf page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(CDX2-cre/ERT2)752Erf expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CDX2 (1045)

  Cdx2	(MGI:88361)

• Mutation details: The transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain), and a bovine growth hormone polyadenylation cassette. This transgene was injected into (C57BL/6J x SJL/J) hybrid cells. Transgenic mice from founder line 752 were bred to C57BL/6J mice. The donating investigator reports that this strain was maintained by breeding hemizygous mice with C57BL/6J inbred mice for at least 4 generations. (J:195262)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CDX2 (human) Summary of all recombinase alleles driven by CDX2. Alliance human CDX2 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(CDX2-cre/ERT2)752Erf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:195262 Fearon E, Generation of a CDX2-cre/ERT2 transgene. MGI Direct Data Submission. 2013
• All: 28 reference(s)