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Tg(TARDBP*A315T)#Jpj
Transgene Detail
Nomenclature
Symbol: Tg(TARDBP*A315T)#Jpj
Name: transgene insertion, Jean-Pierre Julien
MGI ID: MGI:5476824
Synonyms: TDP-43A315T
Transgene: Tg(TARDBP*A315T)#Jpj  Location: unknown  
Transgene
origin
Strain of Origin:  C3H x C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TARDBP*A315T)#Jpj expresses 1 gene
 
Mutation detailsThis transgene consists of TARDBP amplified by PCR from a human BAC clone (clone RPCI-11, clone number 829B14) with the endogenous promoter and an A315T mutation inserted using site-directed mutagenesis. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:195184)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:195184 Swarup V, et al., Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments. Brain. 2011 Sep;134(Pt 9):2610-26
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory