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Map3k8tm1.2Gkl
Targeted Allele Detail
Nomenclature
Symbol: Map3k8tm1.2Gkl
Name: mitogen-activated protein kinase kinase kinase 8; targeted mutation 1.2, George Kollias
MGI ID: MGI:5476711
Synonyms: Tpl2D
Gene: Map3k8  Location: Chr18:4331325-4352953 bp, - strand  Genetic Position: Chr18, 2.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193546
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre-mediated recombination removed the floxed exon 4. (J:193546, J:216678)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map3k8 Mutation:  21 strains or lines available
References
Original:  J:193546 Koliaraki V, et al., Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis. J Clin Invest. 2012 Nov 1;122(11):4231-42
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory