About   Help   FAQ
Rgs4tm1.1Amus
Targeted Allele Detail
Summary
Symbol: Rgs4tm1.1Amus
Name: regulator of G-protein signaling 4; targeted mutation 1.1, Anthony J Muslin
MGI ID: MGI:5476691
Gene: Rgs4  Location: Chr1:169569046-169575211 bp, - strand  Genetic Position: Chr1, 76.84 cM
Alliance: Rgs4tm1.1Amus page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195186
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 5. Cre-mediated recombination removed exons 2 through 5 and the neo cassette. RT-PCR confirmed the absence of transcript expression in cardiac tissue. (J:195186)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rgs4 Mutation:  18 strains or lines available
References
Original:  J:195186 Siedlecki A, et al., RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity. Am J Transplant. 2010 Feb;10(2):231-41
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory