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Targeted Allele Detail
Symbol: Stx11tm1.2Ics
Name: syntaxin 11; targeted mutation 1.2, Mouse Clinical Institute
MGI ID: MGI:5476622
Gene: Stx11  Location: Chr10:12813953-12840042 bp, - strand  Genetic Position: Chr10, 4.54 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:193137
Parent Cell Line:  BD10 (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA resistance cassette (FRT site, neo resistance gene, loxP site, FRT site and loxP site) was inserted downstream of exon 3. An additional loxP site was inserted upstream of exon 3. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exon 3. Western blot analysis confirmed the absence of protein expression in CD8+ T cells. (J:193137)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stx11 Mutation:  7 strains or lines available
Original:  J:193137 Sepulveda FE, et al., Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013 Jan 24;121(4):595-603
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory