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b2b1879Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b1879Clo
Name: Mutant line 1879; Bench to Bassinet Program (B2B/CVDC), mutation 1879 Cecilia Lo
MGI ID: MGI:5476173
Synonyms: Carter
Gene: b2b1879Clo  Location: unknown  
Mutant 1879-002-NA shows ventricular hypertrophy and abnormal placement of the outflow with malformed pulmonary trunk

Show the 24 image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b1879Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Mutant Type 1:
Cardiac phenotype: Persistant truncus arterosis (PTA) with left persistent ductus arteriosus (PDA), overriding aorta, double outlet right ventricle (DORV), myocardial non-compaction, biventricular hypertrophy, muscular ventricular septal defect (mVSD)
Noncardiac phenotype: Cleft palate, micrognathia

Mutant Type 2:
Noncardiac phenotype: Kidney agenesis

Phenotypic Similarity to Human Syndrome: DiGeorge Syndrome

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0500 Truncus arteriosus
0510 Truncus arteriosus type i
0600 Double outlet right ventricle
1320 Ventricular septal defect, muscular
1802 Excessive myocardial trabeculation or noncompaction
4163 Micrognathia
4503 Agenesis of kidneys
4610 DiGeorge syndrome
4876 Cleft palate
7505 Biventricular hypertrophy

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program. MGI Direct Data Submission (B2B/CvDC). 2011-13;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory