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Cdkl5tm1.1Joez
Targeted Allele Detail
Nomenclature
Symbol: Cdkl5tm1.1Joez
Name: cyclin-dependent kinase-like 5; targeted mutation 1.1, Zhaolan Zhou
MGI ID: MGI:5475468
Gene: Cdkl5  Location: ChrX:160784308-160994681 bp, - strand  Genetic Position: ChrX, 73.95 cM
Hindlimb clasping in Cdkl5tm1.1Joez/Y mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193172
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 6. A loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette and exon 6. Western blot analysis confirmed the absence of protein expression. (J:193172)
Generation of the Cdkl5tm1.1Joez allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkl5 Mutation:  13 strains or lines available
References
Original:  J:193172 Wang IT, et al., Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21516-21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory