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Pkn1tm1Kik
Targeted Allele Detail
Summary
Symbol: Pkn1tm1Kik
Name: protein kinase N1; targeted mutation 1, Hitoshi Kikutani
MGI ID: MGI:5475202
Gene: Pkn1  Location: Chr8:84393165-84425808 bp, - strand  Genetic Position: Chr8, 40.22 cM
Alliance: Pkn1tm1Kik page
Development of glomerulonephritis in Pkn1tm1Kik/Pkn1tm1Kik mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:193187
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 through 6 were replaced with a neo cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts and B cells. (J:193187)
Generation of the Pkn1tm1Kik allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkn1 Mutation:  45 strains or lines available
References
Original:  J:193187 Yasui T, et al., Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21022-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory