Epgn^tm1.1Msdr
Targeted Allele Detail

Summary

• Symbol: Epgn^tm1.1Msdr
• Name: epithelial mitogen; targeted mutation 1.1, Marlon R Schneider
• MGI ID: MGI:5475149
• Synonyms: Epgn^del
• Gene: Epgn Location: Chr5:91175376-91183071 bp, + strand Genetic Position: Chr5, 44.78 cM, cytoband E2
• Alliance: Epgn^tm1.1Msdr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194427
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 3 and 4. Cre-mediated recombination removed the neo cassette. Immunofluorescence confirmed the absence of protein expression in the outer root sheath. (J:194427)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epgn Mutation: 16 strains or lines available

References

• Original: J:194427 Dahlhoff M, et al., Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis. Exp Cell Res. 2013 Feb 15;319(4):529-35
• All: 1 reference(s)