Scmh1^tm1Yota
Targeted Allele Detail

Summary

• Symbol: Scmh1^tm1Yota
• Name: sex comb on midleg homolog 1; targeted mutation 1, Yoshihiro Takihara
• MGI ID: MGI:5475146
• Gene: Scmh1 Location: Chr4:120262478-120387383 bp, + strand Genetic Position: Chr4, 56.52 cM, cytoband D1-D2
• Alliance: Scmh1^tm1Yota page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194424
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 3. Western blot analysis confirmed the absence of protein expression in testes. (J:194424)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scmh1 Mutation: 101 strains or lines available

References

• Original: J:194424 Yasunaga S, et al., Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4. Mol Cell Biol. 2013 Feb;33(4):644-60
• All: 1 reference(s)