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Tg(Msr1-MMP9)#Apar
Transgene Detail
Nomenclature
Symbol: Tg(Msr1-MMP9)#Apar
Name: transgene insertion, Annie Pardo
MGI ID: MGI:5475005
Synonyms: hMMP9-TG
Transgene: Tg(Msr1-MMP9)#Apar  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Msr1-MMP9)#Apar expresses 1 gene
 
Mutation detailsThe scavenger receptor A enhancer-promoter drives expression of human MMP9 (2.4 kb cDNA). The Msr1 promoter drives expression specifically in differentiated macrophages. Zymography confirmed expression of MMP9 in peritoneal macrophages. Two lines were established. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:129959)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:129959 Cabrera S, et al., Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin. Int J Biochem Cell Biol. 2007;39(12):2324-38
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory