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Tg(CAG-Bmpr1a*,-lacZ)1Nobs
Transgene Detail
Nomenclature
Symbol: Tg(CAG-Bmpr1a*,-lacZ)1Nobs
Name: transgene insertion 1, Noboru Suzuki
MGI ID: MGI:5473821
Synonyms: Tg(CAG-flox-dnBmpr1a-NLLacZ)1Nobs
Transgene: Tg(CAG-Bmpr1a*,-lacZ)1Nobs  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J x B6;129X1-Pcp2tm1(cre)Nobs
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Dominant negative, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(CAG-Bmpr1a*,-lacZ)1Nobs expresses 1 gene
 
Mutation detailsThis transgene consists of the CAG promoter, loxP flanked stop codon, a 0.6 kb dominant-negative mouse Bmpr1a cDNA lacking the intracellular kinase domain (Y176STOP), a 0.5 kb internal ribosomal entry site (IRES), a 3.5 kb lacZ gene containing the nuclear localization signal, and a polyadenylation signal. Upon Cre-mediated excision of the Stop codon, the modified allele expresses the dominant negative Bmpr1a and lacZ in tissues where Cre is expressed. (J:192670)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:192670 Saito H, et al., Reduced bone morphogenetic protein receptor type 1A signaling in neural-crest-derived cells causes facial dysmorphism. Dis Model Mech. 2012 Nov;5(6):948-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory