Plvap^tm1.2Rvst
Targeted Allele Detail

Summary

• Symbol: Plvap^tm1.2Rvst
• Name: plasmalemma vesicle associated protein; targeted mutation 1.2, Radu V Stan
• MGI ID: MGI:5473518
• Synonyms: PV1^-
• Gene: Plvap Location: Chr8:71950409-71964396 bp, - strand Genetic Position: Chr8, 34.43 cM
• Alliance: Plvap^tm1.2Rvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191046
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a an FRT flanked pgk-EM7-neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Recombinase mediated recombination removed the pgk-EM7-neo cassette and exons 2 - 5. (J:191046)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plvap Mutation: 47 strains or lines available

References

• Original: J:191046 Stan RV, et al., The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition. Dev Cell. 2012 Dec 11;23(6):1203-18
• All: 1 reference(s)