Neurod1^{tm1.1(Atoh7)Whk}
Targeted Allele Detail

Summary

• Symbol: Neurod1^{tm1.1(Atoh7)Whk}
• Name: neurogenic differentiation 1; targeted mutation 1.1, William H Klein
• MGI ID: MGI:5472139
• Synonyms: Neurod1^Atoh7HA3
• Gene: Neurod1 Location: Chr2:79282981-79286980 bp, - strand Genetic Position: Chr2, 47.58 cM
• Alliance: Neurod1^{tm1.1(Atoh7)Whk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxC2 flanked neo cassette in inverse orientation and an Atoh7 cDNA fused to 3 hemagglutinin epitope (HA) tags replaced the entire coding region via homologous recombination. Cre mediated recombination removed the neo cassette. (J:194077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurod1 Mutation: 29 strains or lines available

References

• Original: J:194077 Mao CA, et al., Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7. Development. 2013 Feb 1;140(3):541-51
• All: 1 reference(s)